Sunday, February 9, 2014
CBD Oil Bill Introduced in Kentucky & How to Support It
This week in Kentucky a CBD Oil bill was introduced by Senator Julie Denton (R-Louisville). If passed, doctors affiliated with Kentucky universities that have medical school will be able to prescribe CBD and it may also be used in clinical trials.
This does not limit by age or condition, which is good since science suggests cannabidiol may help a wide array of conditions, not just epilepsy. Anything from cancer, strokes, Crohn's Disease, Multiple Sclerosis, Parkinson's Disease, and Diabetes to name a few. I will link some of that research at the bottom of this page and the sheer volume will overwhelm you. Read it then answer this question: don't you want the laws already in place in case God forbid yourself or a loved one develops one of these all too common illnesses?
Sick people need relief, especially given many are exhausting pharmaceutical options. Since beginning this campaign in November my son has failed another pharmaceutical anticonvulsant. This time an adverse reaction to the medication itself gave him the impulse control of a toddler. He was running in front of cars, trying to pull boiling pots of water onto himself, sticking his hand in the garbage disposal, and otherwise harming himself and others. This drug carries the risk of suicidal impulses. Is doing dangerous stuff how suicidal impulses manifest in the minimally verbal? How am I supposed to even know? Thankfully, he has calmed down since we titrated down that drug, but there is still the matter of complete epilepsy control, which we've never attained with anything except steroids. CBD oil can't come to Kentucky fast enough!
Special thanks to Senator Denton and the other co-sponsors of SB 124.
Please read the bill and support SB 124. Call your Senator at 1-800-372-7181 and ask him or her to support SB 124. If you don't know who your senator is give the operator your zip code and she will deliver the message. Thank you.
Suzanne M. De Gregorio
February 9th, 2014
Research into Cannabidiol for various conditions. This list is by no means complete. I just had to stop somewhere.
Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
Breast Cancer Res Treat. 2012 May;133(1):401-4.
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.Mol Cancer Ther. 2007 Nov;6(11):2921-7.
PLoS One. 2011;6(9):e23901. doi: 10.1371/journal.pone.0023901. Epub 2011 Sep 7.
Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion.
Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinomaAmerican Society for Pharmacology and Experimental Therapeutics
Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibitionMolecular Cancer 2010, 9:196
Cannabinoids: a new hope for breast cancer therapy?
Cancer Treat Rev. 2012 Nov;38(7):911-8.
The endogenous cannabinoid anandamide inhibits human breastcancer cell proliferationProc. Natl. Acad. Sci. USAVol. 95, pp. 8375–8380, July 1998
Cannabis Compound May Stop Metastatic Breast Cancer - ABC News
*There is research for cannabidiol and other types of cancer, but in the interest of space I'm focusing on the most common one. For a more complete list click here.
Pharmaceuticals 2010, 3(7), 2197-2212; doi:10.3390/ph3072197
Therapeutic Potential of Non-Psychotropic Cannabidiol in Ischemic Stroke
Cannabidiol Prevents Cerebral Infarction Via a Serotonergic 5-Hydroxytryptamine1A Receptor–Dependent Mechanism
Journal - Stroke
Autoimmunity. 2006 Mar;39(2):143-51.
Cannabidiol lowers incidence of diabetes in non-obese diabetic mice.
Curr Pharmacogenomics Person Med. 2009 September; 7(3): 215–222.
Cannabidiol As a Putative Novel Therapy for Diabetic Retinopathy: A Postulated Mechanism of Action as an Entry Point for Biomarker-Guided Clinical Development
Cannabidiol Arrests Onset of Autoimmune Diabetes in NOD MiceNeuropharmacology. 2008 January; 54(1): 244–249.
Rev. Bras. Psiquiatr. vol.30 no.3 São Paulo Sept. 2008
Cannabidiol: from an inactive cannabinoid to a drug with wide spectrum of action
Am J Physiol Heart Circ Physiol. 2007 July; 293(1): H610–H619.
Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
Eur J Pharmacol. 2013 Nov 15;720(1-3):376-82. 2013 Oct 8.
Cannabinoids alter endothelial function in the Zucker rat model of type 2 diabetes.
Free Radic Biol Med. 2011 Sep 1;51(5):1054-61. 2011 Jan 14.
Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress.
Crohns's Disease and Colitis
Cannabidiol Reduces Intestinal Inflammation through the Control of Neuroimmune Axis Mariateresa Cipriano, Published: December 06, 2011•DOI: 10.1371/journal.pone.0028159
Cannabidiol in Inflammatory Bowel Diseases: ABrief OverviewPHYTOTHERAPY RESEARCHPhytother. Res. (2012)
Z Gastroenterol 2011; 49 - A12
Effect of different dose cannabidiol treatment on experimental induced colitis
Cytokine. 2014 Feb;65(2):236-44. doi: 10.1016/j.cyto.2013.10.006. Epub 2013 Nov 13.
Interleukin 17A evoked mucosal damage is attenuated by cannabidiol and anandamide in a human colonic explant model.
Pharmacology. 2012;89(3-4):149-55. doi: 10.1159/000336871. Epub 2012 Mar 12.
Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice.
J Mol Med (Berl). 2009 Nov;87(11):1111-21. doi: 10.1007/s00109-009-0512-x. Epub 2009 Aug 20.
Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis.
Autism & Epilepsy
There are dozens of animal model studies and a case series report on epilepsy and a few on autism. Rather than re-list them all now click here for the full list.
**Please note: other sativa and indica strains can work in synergy with high CBD strains to produce even better medicinal impact for conditions like cancer and PTSD (which plagues our veterans at record numbers now). SB 124 legalizes the high CBD (cannabidiol) strain. Therefore, please also take a look at SB 43, which would legalize all of them for medicinal purposes only and consider supporting it as well. Thank you.