De-stigmatizing a plant for suffering children everywhere


Thursday, April 3, 2014

Cannabidiol (CBD) & Breast Cancer Links





The local media focuses on epilepsy, since that community lead the charge for cannabidiol in Kentucky, but the new law actually does not limit by condition. It merely declassifies cannabidiol from the definition of marijuana and allows doctors affiliated with The University of Kentucky and The University of Louisville to prescribe high CBD products or use them in clinical trials. Even though no product is available yet in Kentucky, it can't hurt to start those conversations with doctors now so that ground is already covered by the time CBD Oil arrives.

Since I am currently being treated for breast cancer, I want to bring all the animal model research on cannabidiol and that condition to my doctor at James Graham Brown Cancer Center. I needed a place to store those links, so I decided to create a post on this blog for them, even though this is an autism and epilepsy website. Later I will add links for other forms of cancer so patients interested in bringing research to their own doctors can print them. At a later date I may make a separate website for CBD and cancer, but right now I'm busy with autism and epilepsy.

Cannabidiol and Breast Cancer Links

Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
Breast Cancer Res Treat. 2012 May;133(1):401-4.

Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells.Mol Cancer Ther. 2007 Nov;6(11):2921-7.

PLoS One. 2011;6(9):e23901. d oi: 10.1371/journal.pone.0023901. Epub 2011 Sep 7.
Crosstalk between chemokine receptor CXCR4 and cannabinoid receptor CB2 in modulating breast cancer growth and invasion.

Anti-tumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinomaAmerican Society for Pharmacology and Experimental Therapeutics

Cannabinoids reduce ErbB2-driven breast cancer progression through Akt inhibitionMolecular Cancer 2010, 9:196

Cannabinoids: a new hope for breast cancer therapy?
Cancer Treat Rev. 2012 Nov;38(7):911-8.

The endogenous cannabinoid anandamide inhibits human breastcancer cell proliferationProc. Natl. Acad. Sci. USAVol. 95, pp. 8375–8380, July 1998

Cannabis Compound May Stop Metastatic Breast Cancer - ABC News


Animal Model Studies on Cannabidiol and Protection From Chemo Side Effects

Cannabidiol Inhibits Paclitaxel Neuropathic Pain Through 5-HT(1A) Receptors Without Diminishing Nervous System Functioning or Chemo Efficacy
British Journal of Pharmacology, February 14, 2014

Cardioprotective Effect of Rats Exposed to Doxorubicin Toxicity
Environmental Toxicology, September 2013

16 comments:

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    ReplyDelete
  2. Hi, Nigel. That is true. I started taking an already legal high CBD hemp oil (RSHO) to try to reduce side effects from chemo, since there is some animal model dating suggesting it might. I am doing excellent on chemo, hasn't slowed me down nearly as much as I expect. Hard to tell if that is due to my relative youth (43), my basic health nuttery, or the CBD oil. I was completely surprised by the wonderful effect this product has on my brain (improved attention, processing, reduced sound sensitivity). I will never not take it.

    But the reason we need to start conversations with our doctors is because while some people, like me, might do fine on the already legal hemp strains, some might not and would do best on the hemp/cannabis hybrid CBD strains that will now be allowed to be grown in Kentucky for medicinal purposes. Plus, we have plans in the works to bring the costs down by fundraising here, at least for the children. I pay $180 a tube, which lasts me a month, but a person with epilepsy might go through such a tube every three days. So it is about opening options in the Bluegrass State.

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